CLK3

Across TCGA cell cohorts, CLK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,530 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLK3-associated GO terms across cancer lineages are Cerebral cortex neuron differentiation, Phagosome-lysosome fusion, and Regulation of heterochromatin organization. Each is linked with CLK3 in more than 8 cancer types. Because this analysis shows association rather than direction, both CLK3-to-partner and partner-to-CLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cerebral cortex neuron differentiation grouped by CLK3-low versus CLK3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK3→partner) and Y-score (partner→CLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Cerebral cortex neuron differentiation →	+0.206	+0.550	<.001	<.001	3	9
LIVER	Phagosome-lysosome fusion →	+0.086	+0.397	.005	.002	3	7
URINARY_TRACT	Regulation of heterochromatin organization →	+0.102	+0.561	.002	.001	3	6
LUNG_NSCLC_LUAD	Coenzyme A biosynthetic process →	+0.074	+0.472	.001	.004	2	7
BREAST	Deadenylation-independent decapping of nuclear-transcribed mRNA →	+0.085	+0.498	.005	.006	2	7
SOFT_TISSUE	Fructose 6-phosphate metabolic process →	+0.109	+0.490	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,530 associations by consensus.

Cerebral cortex neuron differentiation by CLK3 expression — SOFT_TISSUE

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