CLK3

Across TCGA cell cohorts, CLK3 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLK3-associated genes across cancer lineages are AGI-6780, WYE-125132, and CI-1033. Each is linked with CLK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLK3-to-partner and partner-to-CLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGI-6780 grouped by CLK3-low versus CLK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK3→partner) and Y-score (partner→CLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AGI-6780 →	+0.455	+2.646	.018	.047	3	1
LARGE_INTESTINE	WYE-125132 →	+0.731	+2.652	.003	.045	3	1
LARGE_INTESTINE	CI-1033 →	+0.802	+2.652	.007	.045	3	1
LARGE_INTESTINE	PF-00299804 →	+0.693	+2.652	.002	.045	2	1
LARGE_INTESTINE	AZD1208 →	+0.383	+2.649	.026	.046	1	1
LARGE_INTESTINE	CP466722 →	+0.449	+2.652	.022	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

AGI-6780 by CLK3 expression — LARGE_INTESTINE

Explore this box plot interactively →