CLK1

Across TCGA patient cohorts, CLK1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLK1-associated genes across cancer lineages are PCNA, 14-3-3_beta, and EGFR_pY1068. Each is linked with CLK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLK1-to-partner and partner-to-CLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CLK1-low versus CLK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK1→partner) and Y-score (partner→CLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.242	+3.700	<.001	.001	3	3
UCEC	14-3-3_beta →	-0.090	-2.195	.007	.009	3	2
UCEC	EGFR_pY1068 →	-0.255	-1.874	.002	.002	3	2
UCEC	ACC1 →	+0.317	+3.598	.009	.001	3	2
UCEC	Shc_pY317 →	-0.177	-2.115	<.001	.016	3	2
UCEC	TFRC →	+0.355	+3.321	.046	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PCNA by CLK1 expression — UCEC

Explore this box plot interactively →