CLK1

Across TCGA cell cohorts, CLK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,627 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLK1-associated GO terms across cancer lineages are Late viral transcription, Regulation of alternative mRNA splicing, via spliceosome, and mRNA 5'-splice site recognition. Each is linked with CLK1 in more than 12 cancer types. Because this analysis shows association rather than direction, both CLK1-to-partner and partner-to-CLK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Late viral transcription grouped by CLK1-low versus CLK1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK1→partner) and Y-score (partner→CLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Late viral transcription →	+0.139	+1.228	<.001	.001	3	13
LUNG_SCLC	Regulation of alternative mRNA splicing, via spliceosome →	+0.116	+1.106	<.001	<.001	3	13
LUNG_SCLC	mRNA 5'-splice site recognition →	+0.108	+0.656	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.138	+0.775	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Protein K48-linked deubiquitination →	+0.075	+0.941	<.001	<.001	3	10
OESOPHAGUS	Negative regulation of hematopoietic stem cell differentiation →	+0.144	+0.882	.006	.002	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,627 associations by consensus.

Late viral transcription by CLK1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →