CLIP4

Across TCGA patient cohorts, CLIP4 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIP4-associated genes across cancer lineages are eIF4E, ERK2, and JNK_pT183_Y185. Each is linked with CLIP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIP4-to-partner and partner-to-CLIP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CLIP4-low versus CLIP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIP4→partner) and Y-score (partner→CLIP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.152	+2.598	.034	.005	3	2
UCEC	ERK2 →	+0.173	+1.906	.008	.015	3	2
UCEC	JNK_pT183_Y185 →	-0.154	-1.906	.007	.015	3	2
UCEC	Annexin-1 →	+0.498	+2.135	.005	.010	3	2
UCEC	STAT3_pY705 →	-0.336	-1.668	<.001	.021	3	2
UCEC	Caspase-8 →	-0.224	-2.295	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by CLIP4 expression — UCEC

Explore this box plot interactively →