CLIP2

Across TCGA pan-cancer cohorts, CLIP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CLIP2 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CLIP2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CLIP2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, LUAD, and COAD are the cancer types where CLIP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.603	0.297	.002	33	view →
LUAD	OS	Quartile	III,IV	0.367	0.849	.007	11	view →
COAD	DFS	Median	III,IV	1.000	0.846	.049	6	view →
LSCC	DFS	Quartile	All	0.183	0.698	.022	5	view →
HNSC	DFS	Median	All	0.967	0.918	.045	2	view →
GBM	OS	Quartile	All	0.652	0.941	.037	1	view →
CCRCC	DFS	Median	IV	0.932	0.382	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CLIP2–PDAC (DFS)

Open the PDAC breakdown →