CLIP1

Across TCGA patient cohorts, CLIP1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIP1-associated genes across cancer lineages are Akt_pT308, Chk2_pT68, and 14-3-3_beta. Each is linked with CLIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLIP1-to-partner and partner-to-CLIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by CLIP1-low versus CLIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIP1→partner) and Y-score (partner→CLIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.450	+2.222	.023	.009	3	3
UCEC	Chk2_pT68 →	-0.162	-3.674	.005	.001	3	3
UCEC	14-3-3_beta →	-0.113	-2.060	<.001	.004	3	2
UCEC	ERK2 →	+0.166	+1.847	.006	.007	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.382	+1.584	.004	.015	3	2
UCEC	Notch1 →	+0.116	+1.353	.008	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Akt_pT308 by CLIP1 expression — UCEC

Explore this box plot interactively →