CLINT1

Across TCGA patient cohorts, CLINT1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLINT1-associated genes across cancer lineages are JNK2, p62 Lck ligand, and 14-3-3_beta. Each is linked with CLINT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLINT1-to-partner and partner-to-CLINT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CLINT1-low versus CLINT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLINT1→partner) and Y-score (partner→CLINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.204	+1.925	.004	.005	3	2
UCEC	p62 Lck ligand →	+0.409	+2.321	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.096	-3.432	.008	.005	3	1
UCEC	EGFR_pY1068 →	-0.240	-2.222	.007	.010	3	1
UCEC	Heregulin →	-0.129	-2.446	.003	.018	3	1
UCEC	INPP4B →	-0.245	-2.321	.035	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

JNK2 by CLINT1 expression — UCEC

Explore this box plot interactively →