CLIC6

Across TCGA pan-cancer cohorts, CLIC6 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CLIC6 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher CLIC6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CLIC6 expression acts as an unfavorable survival marker.

SCLC, LUAD, and SKCM are the cancer types where CLIC6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.137	0.715	<.001	36	view →
LUAD	OS	Median	All	0.141	0.788	<.001	20	view →
SKCM	DFS	Median	II,III,IV	0.087	0.708	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CLIC6–SCLC (OS)

Open the SCLC breakdown →