CLIC6

Across TCGA pan-cancer cohorts, CLIC6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CLIC6 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CLIC6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CLIC6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where CLIC6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.786	0.946	.013	30	view →
LUAD	DFS	Quartile	II,III,IV	0.821	0.339	.009	23	view →
LSCC	OS	Tertile	All	0.975	0.847	.008	6	view →
PDAC	OS	Median	III,IV	0.863	0.661	.019	5	view →
CCRCC	DFS	Tertile	III,IV	0.347	0.692	.014	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CLIC6–HNSC (OS)

Open the HNSC breakdown →