CLIC6

Across TCGA patient cohorts, CLIC6 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,258 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CLIC6-associated proteins across cancer lineages are CLIC6_S377, CLIC6_S293, and CLIC6_S322. Each is linked with CLIC6 in more than 9 cancer types. Because this analysis shows association rather than direction, both CLIC6-to-partner and partner-to-CLIC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLIC6 versus CLIC6_S377 in CCRCC, with a Pearson correlation of 0.91.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC6→partner) and Y-score (partner→CLIC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLIC6_S377 →	+2.774	+2.561	<.001	<.001	3	10
OV	CLIC6_S293 →	+0.937	+1.410	<.001	<.001	3	8
BRCA	CLIC6_S322 →	+1.812	+3.043	<.001	<.001	3	8
GBM	SNX9 →	+0.325	+0.736	<.001	<.001	3	5
OV	CLIC6_S393 →	+1.815	+1.463	.001	.001	3	5
UCEC	CLIC6_S397 →	+2.775	+3.753	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,258 associations by consensus.

CLIC6 vs CLIC6_S377 — CCRCC

Explore this scatter interactively →