CLIC6

Across TCGA patient cohorts, CLIC6 protein abundance is significantly associated with the RNA expression of many other genes, with 12,864 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CLIC6-associated genes across cancer lineages are RGS22, PRKAR2B, and ANKRD6. Each is linked with CLIC6 in more than 6 cancer types. Because this analysis shows association rather than direction, both CLIC6-to-partner and partner-to-CLIC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLIC6 versus RGS22 in BRCA, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC6→partner) and Y-score (partner→CLIC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RGS22 →	+1.205	+1.317	<.001	<.001	3	7
BRCA	PRKAR2B →	+1.375	+1.154	<.001	<.001	3	6
HNSC	ANKRD6 →	+0.542	+0.535	<.001	<.001	3	5
HNSC	CMAHP →	+0.663	+0.551	<.001	.001	3	5
LUAD	CCNA2 →	-0.883	-1.036	.002	<.001	3	4
LUAD	GPR39 →	+0.696	+0.928	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,864 associations by consensus.

CLIC6 vs RGS22 — BRCA

Explore this scatter interactively →