CLIC6

Across TCGA cell cohorts, CLIC6 mutation is significantly associated with the RNA expression of many other genes, with 446 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLIC6-associated genes across cancer lineages are SLC25A31, NEUROD1, and SPANXN4. Each is linked with CLIC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC6-to-partner and partner-to-CLIC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A31 grouped by CLIC6-low versus CLIC6-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC6→partner) and Y-score (partner→CLIC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC25A31 →	+0.007	+3.662	<.001	.005	3	1
LIVER	NEUROD1 →	+0.059	+3.459	<.001	.004	3	1
LIVER	SPANXN4 →	+0.082	+3.459	<.001	.004	3	1
LIVER	ZNF679 →	+0.017	+3.662	.003	.005	3	1
LIVER	MS4A4E →	+0.022	+4.000	<.001	.001	3	1
LIVER	PGA3 →	+0.017	+4.000	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 446 associations by consensus.

SLC25A31 by CLIC6 expression — LIVER

Explore this box plot interactively →