Q-omics provides the consensus-scored CLIC4P3 profile across patient tissues and cancer cell-line models. CLIC4P3 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, CLIC4P3 is differentially expressed in 6, with the highest sampling consensus in HNSC. Additionally, CLIC4P3 RNA expression shows 12,141 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and HNSC as cancer lineages where CLIC4P3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CLIC4P3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CLIC4P3 survival associations across molecular data types. CLIC4P3 RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CLIC4P3 RNA expression–survival associations across cancer types. High CLIC4P3 expression shows unfavorable associations in UVM, MESO, ACC and LGG, but favorable associations in KIRC and SKCM. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for CLIC4P3 RNA expression.
This table summarizes CLIC4P3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for CLIC4P3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CLIC4P3 shows lower tumor expression in STAD, UCEC and THCA and higher tumor expression in HNSC, COAD and LIHC. The HNSC box plot shows higher CLIC4P3 RNA expression in tumor versus normal tissue (log2 FC = +0.101, t-test p = .001).
This table shows molecular features associated with CLIC4P3 in patient tissues and cancer cell lines. In patient samples, CLIC4P3 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
