CLIC3

Across TCGA patient cohorts, CLIC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,150 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CLIC3-associated proteins across cancer lineages are CLIC3_S49, NIBAN2, and PLEC. Each is linked with CLIC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both CLIC3-to-partner and partner-to-CLIC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLIC3 versus CLIC3_S49 in HNSC, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC3→partner) and Y-score (partner→CLIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLIC3_S49 →	+1.418	+1.642	<.001	<.001	3	7
UCEC	NIBAN2 →	+0.436	+1.161	<.001	.003	3	6
LSCC	PLEC →	+0.376	+1.008	.004	.001	3	5
OV	LMO7 →	+0.639	+1.551	<.001	<.001	3	5
HNSC	TBC1D2 →	+0.620	+1.511	<.001	<.001	3	5
COAD	PHF6 →	-0.330	-1.056	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,150 associations by consensus.

CLIC3 vs CLIC3_S49 — HNSC

Explore this scatter interactively →