CLIC3

Across TCGA patient cohorts, CLIC3 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CLIC3-associated genes across cancer lineages are CD8+ T-cells, CD4+ naive T-cells, and NK cells. Each is linked with CLIC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC3-to-partner and partner-to-CLIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by CLIC3-low versus CLIC3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC3→partner) and Y-score (partner→CLIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD8+ T-cells →	+0.059	+5.142	<.001	.041	3	2
COAD	CD4+ naive T-cells →	+0.031	+5.142	<.001	.041	3	2
STAD	NK cells →	+0.009	+5.597	<.001	.040	3	1
COAD	CD8+ Tcm →	+0.101	+4.917	<.001	.048	3	1
COAD	B-cells →	+0.136	+4.408	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CD8+ T-cells by CLIC3 expression — COAD

Explore this box plot interactively →