CLIC3

Across TCGA cell cohorts, CLIC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,984 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLIC3-associated GO terms across cancer lineages are Small GTPase-mediated signal transduction, Regulation of amyloid fibril formation, and Membrane assembly. Each is linked with CLIC3 in more than 12 cancer types. Because this analysis shows association rather than direction, both CLIC3-to-partner and partner-to-CLIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Small GTPase-mediated signal transduction grouped by CLIC3-low versus CLIC3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC3→partner) and Y-score (partner→CLIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.060	+2.851	<.001	<.001	3	13
STOMACH	Regulation of amyloid fibril formation →	+0.167	+3.949	.001	<.001	3	12
PANCREAS	Membrane assembly →	+0.111	+2.109	<.001	<.001	3	11
OESOPHAGUS	Protein localization to plasma membrane →	+0.090	+4.178	.001	<.001	3	11
OESOPHAGUS	Rho protein signal transduction →	+0.116	+2.679	<.001	<.001	3	11
STOMACH	Regulation of apoptotic signaling pathway →	+0.063	+3.172	.003	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,984 associations by consensus.

Small GTPase-mediated signal transduction by CLIC3 expression — URINARY_TRACT

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