CLIC2

Across TCGA patient cohorts, CLIC2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,472 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLIC2-associated genes across cancer lineages are GIMAP2, GIMAP6, and GYPC. Each is linked with CLIC2 in more than 9 cancer types. Because this analysis shows association rather than direction, both CLIC2-to-partner and partner-to-CLIC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLIC2 versus GIMAP2 in HNSC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC2→partner) and Y-score (partner→CLIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GIMAP2 →	+0.937	+0.514	<.001	<.001	3	10
HNSC	GIMAP6 →	+0.990	+0.498	<.001	<.001	3	10
OV	GYPC →	+1.223	+0.658	<.001	<.001	3	10
LSCC	FLI1 →	+0.855	+0.641	<.001	<.001	3	10
HNSC	GIMAP7 →	+1.174	+0.487	<.001	<.001	3	10
HNSC	RCSD1 →	+0.954	+0.572	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,472 associations by consensus.

CLIC2 vs GIMAP2 — HNSC

Explore this scatter interactively →