CLIC2

Across TCGA patient cohorts, CLIC2 mutation is significantly associated with the RNA expression of many other genes, with 444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIC2-associated genes across cancer lineages are SNORA10B, MIR7155, and SNORD3B-2. Each is linked with CLIC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLIC2-to-partner and partner-to-CLIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA10B grouped by CLIC2-low versus CLIC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC2→partner) and Y-score (partner→CLIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNORA10B →	+0.906	+4.693	<.001	.007	3	3
UCEC	MIR7155 →	+0.290	+2.524	<.001	.006	3	2
UCEC	SNORD3B-2 →	+0.504	+2.180	.004	.002	3	2
COAD	RN7SL98P →	+0.304	+6.278	<.001	<.001	3	2
COAD	MTND4P33 →	+0.146	+5.122	<.001	.004	3	2
UCEC	DRD2 →	-0.488	-2.641	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 444 associations by consensus.

SNORA10B by CLIC2 expression — COAD

Explore this box plot interactively →