CLIC2

Across TCGA patient cohorts, CLIC2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIC2-associated genes across cancer lineages are eEF2, mTOR_pS2448, and Annexin-1. Each is linked with CLIC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC2-to-partner and partner-to-CLIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CLIC2-low versus CLIC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC2→partner) and Y-score (partner→CLIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.304	+3.000	.039	.036	3	2
UCEC	mTOR_pS2448 →	-0.131	-2.986	.033	.035	3	2
UCEC	Annexin-1 →	+0.512	+2.479	.018	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.179	-3.321	.009	.010	3	1
UCEC	MSH2 →	-0.313	-3.575	<.001	.002	3	1
UCEC	Myosin-IIa →	+0.212	+2.332	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eEF2 by CLIC2 expression — UCEC

Explore this box plot interactively →