CLIC2

Across TCGA cell cohorts, CLIC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,852 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLIC2-associated GO terms across cancer lineages are Intrinsic apoptotic signaling pathway, Maintenance of protein location in cell, and Maintenance of protein location. Each is linked with CLIC2 in more than 8 cancer types. Because this analysis shows association rather than direction, both CLIC2-to-partner and partner-to-CLIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intrinsic apoptotic signaling pathway grouped by CLIC2-low versus CLIC2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC2→partner) and Y-score (partner→CLIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Intrinsic apoptotic signaling pathway →	+0.057	+0.624	<.001	.004	3	9
SOFT_TISSUE	Maintenance of protein location in cell →	+0.142	+1.181	<.001	.001	3	8
SOFT_TISSUE	Maintenance of protein location →	+0.142	+1.165	<.001	.001	3	8
BLOOD_Lymphoma	Cellular response to type I interferon →	+0.108	+1.256	<.001	.006	3	8
SKIN	Regulation of myeloid cell differentiation →	+0.051	+0.736	<.001	.003	3	8
CNS	Endosomal transport →	+0.024	+0.762	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,852 associations by consensus.

Intrinsic apoptotic signaling pathway by CLIC2 expression — URINARY_TRACT

Explore this box plot interactively →