CLIC2

Across TCGA cell cohorts, CLIC2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLIC2-associated genes across cancer lineages are REG1B, OR10W1, and CCL25. Each is linked with CLIC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC2-to-partner and partner-to-CLIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by CLIC2-low versus CLIC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC2→partner) and Y-score (partner→CLIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.538	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1
SKIN	CCL25 →	+0.060	+4.095	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

REG1B by CLIC2 expression — LARGE_INTESTINE

Explore this box plot interactively →