Across TCGA pan-cancer cohorts, CLIC1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CLIC1 data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher CLIC1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CLIC1 expression acts as an unfavorable survival marker.

OV, BRCA, and CESC are the cancer types where CLIC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.295	0.843	<.001	36	view →
BRCA	OS	Median	All	0.110	0.578	.013	18	view →
CESC	OS	Median	All	0.271	0.798	.010	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: CLIC1 tumor-vs-normal RNA expression · all CLIC1 data types