Across TCGA patient cohorts, CLIC1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,290 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLIC1-associated genes across cancer lineages are SERPINB1, PPP1R11, and TAPBP. Each is linked with CLIC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CLIC1-to-partner and partner-to-CLIC1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC1→partner) and Y-score (partner→CLIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SERPINB1 →	+0.892	+0.242	<.001	<.001	3	7
OV	PPP1R11 →	+0.459	+0.348	<.001	<.001	3	6
OV	TAPBP →	+1.174	+0.328	<.001	.002	3	6
PDAC	ERO1A →	+1.008	+0.261	<.001	<.001	3	5
GBM	PAIP2B →	-1.142	-0.458	<.001	.001	3	5
GBM	MAPK13 →	+0.834	+0.492	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,290 associations by consensus.

Exploration

CLIC1 survival (RNA) · tumor vs normal (RNA) · all CLIC1 data types