Across TCGA patient cohorts, CLIC1 mutation is significantly associated with the RNA expression of many other genes, with 534 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIC1-associated genes across cancer lineages are RN7SL311P, MTCO1P5, and MIR1976. Each is linked with CLIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC1-to-partner and partner-to-CLIC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC1→partner) and Y-score (partner→CLIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL311P →	+0.207	+2.921	<.001	.001	3	2
UCEC	MTCO1P5 →	+0.614	+3.039	<.001	.001	3	2
UCEC	MIR1976 →	+0.507	+2.631	<.001	.007	3	2
UCEC	ATP1B3P1 →	+0.325	+3.235	<.001	.009	3	1
UCEC	SNORD116-22 →	+0.251	+3.115	.004	.007	3	1
UCEC	RNA5SP411 →	+0.924	+2.171	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 534 associations by consensus.

Exploration

CLIC1 survival (RNA) · tumor vs normal (RNA) · all CLIC1 data types