Across TCGA patient cohorts, CLIC1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLIC1-associated genes across cancer lineages are FoxM1, Ku80, and Rad50. Each is linked with CLIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC1-to-partner and partner-to-CLIC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC1→partner) and Y-score (partner→CLIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.313	+3.331	.021	.005	3	1
UCEC	Ku80 →	+0.301	+3.335	.015	.005	3	1
UCEC	Rad50 →	-0.284	-3.321	.025	.010	3	1
UCEC	STAT3_pY705 →	-0.477	-3.321	<.001	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.680	+2.827	.028	.035	2	2
UCEC	Cyclin-B1 →	+0.653	+3.321	.026	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

CLIC1 survival (RNA) · tumor vs normal (RNA) · all CLIC1 data types