Across TCGA cell cohorts, CLIC1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLIC1-associated genes across cancer lineages are IFNG, OLFM3, and FAM71F1. Each is linked with CLIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC1-to-partner and partner-to-CLIC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC1→partner) and Y-score (partner→CLIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IFNG →	+0.116	+3.304	.001	.001	3	1
BLOOD_Leukemia	OLFM3 →	+0.732	+3.697	<.001	.002	3	1
BLOOD_Leukemia	FAM71F1 →	+0.162	+4.058	<.001	.001	3	1
BLOOD_Leukemia	MYOCD →	+0.667	+2.938	.003	.008	3	1
BLOOD_Leukemia	ODF1 →	+0.062	+2.681	<.001	.008	3	1
BLOOD_Leukemia	LRRC38 →	+1.197	+3.318	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

CLIC1 survival (RNA) · tumor vs normal (RNA) · all CLIC1 data types