Across TCGA cell cohorts, CLIC1 mutation is significantly associated with the mutation status of many other genes, with 2,726 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLIC1-associated genes across cancer lineages are KCTD11, ZNF688, and ZNF224. Each is linked with CLIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLIC1-to-partner and partner-to-CLIC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLIC1→partner) and Y-score (partner→CLIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCTD11 →	+5.083	+3.672	.001	.001	1	2
BLOOD_Leukemia	ZNF688 →	+4.498	+3.700	<.001	<.001	1	2
BLOOD_Leukemia	ZNF224 →	+4.083	+3.338	.003	.003	1	2
BLOOD_Leukemia	TGOLN2 →	+5.820	+4.285	<.001	<.001	1	2
BLOOD_Leukemia	FBXL18 →	+3.176	+4.544	<.001	<.001	1	2
BLOOD_Leukemia	DRC1 →	+5.083	+3.672	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,726 associations by consensus.

Exploration

CLIC1 survival (RNA) · tumor vs normal (RNA) · all CLIC1 data types