CLGN

Across TCGA pan-cancer cohorts, CLGN mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CLGN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CLGN mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CLGN is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where CLGN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLGN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−0.705	.005	4	view →
PDAC	Female	All	−1.157	.001	3	view →
LSCC	All	All	+0.386	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CLGN–HNSC

Open the HNSC breakdown →