Across TCGA patient cohorts, CLEC6A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC6A-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1, and GSK-3a-b_pS21_S9. Each is linked with CLEC6A in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC6A-to-partner and partner-to-CLEC6A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC6A→partner) and Y-score (partner→CLEC6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.563	+2.817	.002	.036	3	2
SKCM	4E-BP1 →	+0.292	+2.584	.038	.011	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.492	+2.817	.046	.036	3	1
UCEC	MEK1 →	+0.485	+3.000	.021	.037	3	1
UCEC	Annexin_VII →	-0.160	-3.000	.047	.037	3	1
UCEC	SETD2 →	-0.266	-3.000	.035	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

CLEC6A survival (RNA) · tumor vs normal (RNA) · all CLEC6A data types