CLEC4GP1

Across TCGA pan-cancer cohorts, CLEC4GP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CLEC4GP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CLEC4GP1 RNA is repressed in tumor relative to normal tissue. In most cancer types CLEC4GP1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, BRCA, and BLCA are the cancer types where CLEC4GP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLEC4GP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.316	<.001	11	view →
BRCA	All	II,III,IV	−0.956	<.001	8	view →
BLCA	All	III,IV	−0.733	.005	8	view →
KIRP	All	III,IV	−0.335	<.001	7	view →
LUSC	All	All	−0.471	<.001	6	view →
LIHC	Male	All	−0.345	<.001	6	view →
LUAD	All	All	−0.233	.009	5	view →
KICH	Female	III,IV	+2.630	<.001	4	view →
HNSC	Male	All	−0.356	.020	4	view →
STAD	All	All	−0.337	.002	4	view →
COAD	Female	II,III,IV	−0.258	.003	4	view →
CHOL	All	II,III,IV	−1.114	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CLEC4GP1–KIRC

Open the KIRC breakdown →