CLEC4G

Across TCGA patient cohorts, CLEC4G RNA expression is significantly associated with the go_rna of many other GO terms, with 7,162 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CLEC4G-associated GO terms across cancer lineages are Negative regulation of leukocyte cell-cell adhesion, Positive regulation of alpha-beta T cell activation, and Regulation of phagocytosis. Each is linked with CLEC4G in more than 24 cancer types. Because this analysis shows association rather than direction, both CLEC4G-to-partner and partner-to-CLEC4G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of leukocyte cell-cell adhesion grouped by CLEC4G-low versus CLEC4G-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC4G→partner) and Y-score (partner→CLEC4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of leukocyte cell-cell adhesion →	+0.048	+0.246	<.001	<.001	3	25
ESCA	Positive regulation of alpha-beta T cell activation →	+0.059	+0.358	<.001	<.001	3	25
ESCA	Regulation of phagocytosis →	+0.065	+0.630	<.001	<.001	3	24
UVM	Zymogen inhibition →	+0.062	+0.302	<.001	<.001	3	24
STAD	Myeloid cell activation involved in immune response →	+0.058	+0.347	<.001	<.001	3	24
STAD	Regulation of antigen processing and presentation →	+0.075	+0.376	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,162 associations by consensus.

Negative regulation of leukocyte cell-cell adhesion by CLEC4G expression — STAD

Explore this box plot interactively →