CLEC4G

Across TCGA patient cohorts, CLEC4G mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC4G-associated genes across cancer lineages are Tuberin, eIF4G, and p62 Lck ligand. Each is linked with CLEC4G in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC4G-to-partner and partner-to-CLEC4G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by CLEC4G-low versus CLEC4G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC4G→partner) and Y-score (partner→CLEC4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.348	+3.169	.018	.020	3	1
UCEC	eIF4G →	+0.388	+3.169	.022	.020	2	1
UCEC	p62 Lck ligand →	+0.539	+3.169	.002	.020	1	1
UCEC	PDCD4 →	-0.674	-3.169	.009	.020	1	1
UCEC	ASNS →	+0.953	+3.169	<.001	.020	1	1
UCEC	Cyclin-B1 →	+0.884	+3.169	.004	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Tuberin by CLEC4G expression — UCEC

Explore this box plot interactively →