CLEC4F

Across TCGA pan-cancer cohorts, CLEC4F Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CLEC4F data layer compared with 23 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CLEC4F Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CLEC4F expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

CESC, ACC, and LGG are the cancer types where CLEC4F Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.257	0.759	.049	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
COAD	OS	Median	II,III,IV	0.549	0.855	.018	3	view →
LIHC	DFS	Median	All	0.138	0.544	.025	3	view →
LUAD	OS	Median	III,IV	0.508	0.321	.047	2	view →
UCEC	DFS	Median	All	0.956	0.629	.044	2	view →
SKCM	DFS	Median	All	0.488	0.737	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CLEC4F–CESC (OS)

Open the CESC breakdown →