CLEC4D

Across TCGA patient cohorts, CLEC4D mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CLEC4D-associated genes across cancer lineages are Smad1, ACC_pS79, and JNK2. Each is linked with CLEC4D in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC4D-to-partner and partner-to-CLEC4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad1 grouped by CLEC4D-low versus CLEC4D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC4D→partner) and Y-score (partner→CLEC4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smad1 →	-0.190	-3.000	.001	<.001	3	2
SKCM	ACC_pS79 →	+0.258	+1.807	.030	.026	3	1
SKCM	JNK2 →	-0.239	-3.000	.004	.034	3	1
SKCM	MEK1_p_S217_S221 →	+0.254	+2.459	.008	.017	3	1
SKCM	p27 →	-0.160	-1.874	.031	.049	3	1
SKCM	p53 →	+0.264	+2.339	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Smad1 by CLEC4D expression — SKCM

Explore this box plot interactively →