Across TCGA patient cohorts, CLEC4C mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC4C-associated genes across cancer lineages are p38-MAPK_pT180_Y182, p62 Lck ligand, and ATM. Each is linked with CLEC4C in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC4C-to-partner and partner-to-CLEC4C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC4C→partner) and Y-score (partner→CLEC4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.610	-3.000	.009	.036	3	2
UCEC	p62 Lck ligand →	+0.429	+2.179	.011	.034	3	2
UCEC	ATM →	-0.607	-3.321	.010	.010	3	2
UCEC	EGFR_pY1068 →	-0.320	-2.999	.015	.035	3	1
UCEC	eIF4G →	+0.383	+3.321	.018	.010	3	1
UCEC	MEK1 →	+0.570	+3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

CLEC4C survival (RNA) · tumor vs normal (RNA) · all CLEC4C data types