CLEC4A

Across TCGA patient cohorts, CLEC4A mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC4A-associated genes across cancer lineages are FOXO3a_pS318_S321, PCNA, and eIF4E. Each is linked with CLEC4A in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC4A-to-partner and partner-to-CLEC4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CLEC4A-low versus CLEC4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC4A→partner) and Y-score (partner→CLEC4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.153	-3.449	.006	.005	3	2
UCEC	PCNA →	+0.282	+2.000	.003	.032	3	2
UCEC	eIF4E →	+0.226	+3.584	.017	.002	3	1
UCEC	ERK2 →	+0.188	+2.000	.030	.032	3	1
UCEC	GAPDH →	+0.574	+2.999	.017	.035	3	1
UCEC	GSK-3_pS9 →	-0.421	-2.999	.020	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

FOXO3a_pS318_S321 by CLEC4A expression — UCEC

Explore this box plot interactively →