CLEC3B

Across TCGA pan-cancer cohorts, CLEC3B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CLEC3B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CLEC3B RNA is repressed in tumor relative to normal tissue. In most cancer types CLEC3B is over-expressed in tumor, although a few such as BLCA and KIRP show the opposite, repressed pattern.

BLCA, KIRP, and COAD are the cancer types where CLEC3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLEC3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−6.317	<.001	12	view →
KIRP	Male	II,III,IV	−4.349	<.001	11	view →
COAD	Female	II,III,IV	−3.861	<.001	11	view →
KICH	Male	IV	−4.696	<.001	10	view →
HNSC	Male	IV	−3.524	<.001	10	view →
STAD	Male	III,IV	−2.986	<.001	10	view →
KIRC	Male	II,III,IV	−1.376	<.001	10	view →
LUSC	Female	II,III,IV	−5.441	<.001	9	view →
LUAD	Female	III,IV	−4.881	<.001	9	view →
THCA	All	IV	−2.402	<.001	9	view →
UCEC	All	III,IV	−4.242	<.001	6	view →
BRCA	All	II,III,IV	−3.801	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CLEC3B–BLCA

Open the BLCA breakdown →