CLEC2D

Across TCGA patient cohorts, CLEC2D mutation is significantly associated with the RNA expression of many other genes, with 2,470 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC2D-associated genes across cancer lineages are GNPNAT1, CNIH1, and GLRX3. Each is linked with CLEC2D in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC2D-to-partner and partner-to-CLEC2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by CLEC2D-low versus CLEC2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC2D→partner) and Y-score (partner→CLEC2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNPNAT1 →	+0.853	+2.732	<.001	.003	3	2
UCEC	CNIH1 →	+0.581	+3.491	.001	.002	3	2
UCEC	GLRX3 →	+0.716	+3.716	<.001	<.001	3	2
UCEC	PPP1R7 →	+0.365	+3.374	.002	.004	3	2
UCEC	CAB39 →	+0.558	+2.872	.002	.001	3	2
LUSC	MIR6864 →	+0.522	+3.332	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,470 associations by consensus.

GNPNAT1 by CLEC2D expression — UCEC

Explore this box plot interactively →