CLEC2D

Across TCGA patient cohorts, CLEC2D mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC2D-associated genes across cancer lineages are eIF4E, Src_pY527, and GSK-3_pS9. Each is linked with CLEC2D in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC2D-to-partner and partner-to-CLEC2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CLEC2D-low versus CLEC2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC2D→partner) and Y-score (partner→CLEC2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.216	+2.584	.028	.011	3	2
UCEC	Src_pY527 →	-0.513	-3.311	.010	.010	3	2
UCEC	GSK-3_pS9 →	-0.493	-3.321	.008	.010	3	1
UCEC	MEK1 →	+0.515	+3.321	.002	.010	3	1
UCEC	mTOR_pS2448 →	-0.229	-3.439	<.001	.005	2	2
UCEC	PKC-b-II_pS660 →	-0.353	-3.700	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4E by CLEC2D expression — UCEC

Explore this box plot interactively →