CLEC2B

Across TCGA patient cohorts, CLEC2B mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC2B-associated genes across cancer lineages are GSK-3a-b_pS21_S9, S6_pS240_S244, and TFRC. Each is linked with CLEC2B in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC2B-to-partner and partner-to-CLEC2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by CLEC2B-low versus CLEC2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC2B→partner) and Y-score (partner→CLEC2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.497	+3.169	.034	.020	3	1
UCEC	S6_pS240_S244 →	+0.707	+3.169	.001	.020	3	1
UCEC	TFRC →	+0.643	+3.169	.027	.020	1	1
UCEC	Caspase-7-cleavedD198 →	+0.877	+3.169	.007	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GSK-3a-b_pS21_S9 by CLEC2B expression — UCEC

Explore this box plot interactively →