CLEC2B

Across TCGA cell cohorts, CLEC2B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,339 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CLEC2B-associated GO terms across cancer lineages are Positive regulation of canonical NF-kappaB signal transduction, Defense response to virus, and Regulation of macrophage differentiation. Each is linked with CLEC2B in more than 7 cancer types. Because this analysis shows association rather than direction, both CLEC2B-to-partner and partner-to-CLEC2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of canonical NF-kappaB signal transduction grouped by CLEC2B-low versus CLEC2B-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC2B→partner) and Y-score (partner→CLEC2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of canonical NF-kappaB signal transduction →	+0.060	+1.712	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.084	+1.597	<.001	.001	3	8
SOFT_TISSUE	Regulation of macrophage differentiation →	+0.120	+1.708	<.001	<.001	3	8
SOFT_TISSUE	Negative regulation of transcription initiation-coupled chromatin remodeling →	-0.123	-1.484	.006	.002	3	7
BLOOD_Lymphoma	Regulation of CD8-positive, alpha-beta T cell proliferation →	+0.163	+2.117	.001	<.001	3	7
SOFT_TISSUE	Oncostatin-M-mediated signaling pathway →	+0.181	+1.950	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,339 associations by consensus.

Positive regulation of canonical NF-kappaB signal transduction by CLEC2B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →