CLEC1B

Across TCGA cell cohorts, CLEC1B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,068 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLEC1B-associated GO terms across cancer lineages are Negative regulation of phospholipase C/protein kinase C signal transduction, Natural killer cell inhibitory signaling pathway, and Mitochondrial fusion. Each is linked with CLEC1B in more than 2 cancer types. Because this analysis shows association rather than direction, both CLEC1B-to-partner and partner-to-CLEC1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of phospholipase C/protein kinase C signal transduction grouped by CLEC1B-low versus CLEC1B-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC1B→partner) and Y-score (partner→CLEC1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of phospholipase C/protein kinase C signal transduction →	-0.138	-0.570	.003	.001	3	3
BLOOD_Leukemia	Natural killer cell inhibitory signaling pathway →	+0.678	+0.940	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	Mitochondrial fusion →	+0.051	+0.070	.005	.001	3	2
UPPER_AERODIGESTIVE_TRACT	Pyrimidine nucleoside diphosphate metabolic process →	+0.054	+0.052	.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	Positive regulation of nuclear cell cycle DNA replication →	+0.093	+0.060	.005	.006	3	2
UPPER_AERODIGESTIVE_TRACT	Smooth muscle cell migration →	-0.110	-0.054	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,068 associations by consensus.

Negative regulation of phospholipase C/protein kinase C signal transduction by CLEC1B expression — BLOOD_Leukemia

Explore this box plot interactively →