CLEC16A

Across TCGA patient cohorts, CLEC16A mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC16A-associated genes across cancer lineages are PKC-b-II_pS660, Bad_pS112, and eEF2. Each is linked with CLEC16A in more than 2 cancer types. Because this analysis shows association rather than direction, both CLEC16A-to-partner and partner-to-CLEC16A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by CLEC16A-low versus CLEC16A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC16A→partner) and Y-score (partner→CLEC16A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-b-II_pS660 →	+0.332	+3.169	.037	.019	3	2
SKCM	Bad_pS112 →	+0.247	+3.012	.014	.018	3	2
UCEC	eEF2 →	+0.285	+1.807	.019	.004	3	2
UCEC	JNK_pT183_Y185 →	-0.195	-1.794	<.001	.004	3	2
UCEC	MEK1 →	+0.302	+1.514	.015	.015	3	2
UCEC	MSH2 →	-0.275	-2.196	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PKC-b-II_pS660 by CLEC16A expression — SKCM

Explore this box plot interactively →