CLEC16A

Across TCGA cell cohorts, CLEC16A mutation is significantly associated with the RNA expression of many other genes, with 917 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLEC16A-associated genes across cancer lineages are KSR2, METTL6, and OR1L3. Each is linked with CLEC16A in more than 2 cancer types. Because this analysis shows association rather than direction, both CLEC16A-to-partner and partner-to-CLEC16A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR2 grouped by CLEC16A-low versus CLEC16A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC16A→partner) and Y-score (partner→CLEC16A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KSR2 →	+0.401	+3.628	.003	<.001	3	2
BLOOD_Leukemia	METTL6 →	+0.690	+3.231	<.001	.007	3	2
OVARY	OR1L3 →	+0.027	+3.444	.002	.003	3	2
LARGE_INTESTINE	HDDC2 →	+0.682	+2.502	.001	.005	3	2
LARGE_INTESTINE	MTFR1L →	+0.547	+2.502	.003	.005	3	2
LARGE_INTESTINE	MREG →	+0.618	+3.237	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 917 associations by consensus.

KSR2 by CLEC16A expression — LARGE_INTESTINE

Explore this box plot interactively →