CLEC12B

Across TCGA patient cohorts, CLEC12B mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLEC12B-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, PDCD4, and STAT3_pY705. Each is linked with CLEC12B in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC12B-to-partner and partner-to-CLEC12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by CLEC12B-low versus CLEC12B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC12B→partner) and Y-score (partner→CLEC12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.498	+2.817	.035	.036	3	1
UCEC	PDCD4 →	-0.579	-3.160	.008	.019	3	1
UCEC	STAT3_pY705 →	-0.541	-1.874	<.001	.049	3	1
UCEC	Tuberin →	+0.480	+3.469	<.001	.002	3	1
UCEC	VHL →	-0.776	-3.321	.014	.010	3	1
UCEC	ASNS →	+0.441	+3.321	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Acetyl-a-Tubulin-Lys40 by CLEC12B expression — UCEC

Explore this box plot interactively →