CLEC12B

Across TCGA cell cohorts, CLEC12B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,300 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLEC12B-associated GO terms across cancer lineages are Natural killer cell inhibitory signaling pathway, Urokinase plasminogen activator signaling pathway, and Cellular response to angiotensin. Each is linked with CLEC12B in more than 9 cancer types. Because this analysis shows association rather than direction, both CLEC12B-to-partner and partner-to-CLEC12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Natural killer cell inhibitory signaling pathway grouped by CLEC12B-low versus CLEC12B-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC12B→partner) and Y-score (partner→CLEC12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Natural killer cell inhibitory signaling pathway →	+0.707	+1.240	<.001	<.001	3	10
CNS	Urokinase plasminogen activator signaling pathway →	+0.321	+0.166	.003	.009	3	4
BLOOD_Leukemia	Cellular response to angiotensin →	+0.113	+0.924	<.001	<.001	3	4
BLOOD_Leukemia	Carbohydrate derivative catabolic process →	+0.042	+1.088	<.001	.004	3	4
CNS	Organelle disassembly →	+0.029	+0.184	<.001	.003	3	4
KIDNEY	Positive regulation of stem cell proliferation →	+0.136	+0.021	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,300 associations by consensus.

Natural killer cell inhibitory signaling pathway by CLEC12B expression — BLOOD_Leukemia

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