CLEC12A

Across TCGA cell cohorts, CLEC12A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,833 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLEC12A-associated GO terms across cancer lineages are Natural killer cell inhibitory signaling pathway, Homologous chromosome segregation, and Negative regulation of lipoprotein particle clearance. Each is linked with CLEC12A in more than 3 cancer types. Because this analysis shows association rather than direction, both CLEC12A-to-partner and partner-to-CLEC12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Natural killer cell inhibitory signaling pathway grouped by CLEC12A-low versus CLEC12A-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC12A→partner) and Y-score (partner→CLEC12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Natural killer cell inhibitory signaling pathway →	+0.691	+2.903	<.001	<.001	3	4
BLOOD_Leukemia	Homologous chromosome segregation →	-0.057	-1.578	<.001	<.001	3	4
BLOOD_Leukemia	Negative regulation of lipoprotein particle clearance →	+0.155	+2.061	<.001	.001	3	3
BLOOD_Leukemia	sno(s)RNA catabolic process →	-0.102	-1.791	<.001	<.001	3	3
BLOOD_Leukemia	Positive regulation of synaptic vesicle recycling →	-0.117	-2.607	<.001	<.001	3	3
BLOOD_Leukemia	Glycine import across plasma membrane →	-1.112	-1.899	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,833 associations by consensus.

Natural killer cell inhibitory signaling pathway by CLEC12A expression — BLOOD_Leukemia

Explore this box plot interactively →