CLEC12A

Across TCGA cell cohorts, CLEC12A mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLEC12A-associated genes across cancer lineages are ASPN, C6orf118, and PCGF1. Each is linked with CLEC12A in more than 1 cancer types. Because this analysis shows association rather than direction, both CLEC12A-to-partner and partner-to-CLEC12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by CLEC12A-low versus CLEC12A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLEC12A→partner) and Y-score (partner→CLEC12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.049	+2.841	<.001	.002	3	1
LARGE_INTESTINE	C6orf118 →	+0.127	+3.015	<.001	<.001	3	1
LARGE_INTESTINE	PCGF1 →	+0.422	+3.212	.004	.006	3	1
LARGE_INTESTINE	BCAS2 →	+0.630	+3.212	.001	.006	3	1
LARGE_INTESTINE	KCNMB4 →	+1.263	+3.212	<.001	.006	3	1
LARGE_INTESTINE	NTMT1 →	+0.518	+3.067	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ASPN by CLEC12A expression — LARGE_INTESTINE

Explore this box plot interactively →