CLDN7

Across TCGA patient cohorts, CLDN7 protein abundance is significantly associated with the RNA expression of many other genes, with 1,157 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CLDN7-associated genes across cancer lineages are EPB41L4A, RNU12-2P, and RPL7P11. Each is linked with CLDN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN7-to-partner and partner-to-CLDN7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN7 versus EPB41L4A in HNSC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN7→partner) and Y-score (partner→CLDN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EPB41L4A →	+0.952	+3.081	.003	<.001	3	2
LSCC	RNU12-2P →	+2.522	+3.899	.001	.008	3	2
HNSC	RPL7P11 →	+0.808	+2.805	.003	.001	3	2
HNSC	CIART →	+1.152	+2.366	.002	.002	3	2
HNSC	RAB40B →	+0.966	+2.307	.009	.009	3	2
HNSC	SENP8 →	+0.580	+2.720	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,157 associations by consensus.

CLDN7 vs EPB41L4A — HNSC

Explore this scatter interactively →